Positive regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPON1, TLN2, and ADARB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation involved in lung morphogenesis activity versus SPON1 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPON1 →	+0.875	+0.064	<.001	<.001	3	6
BRCA	TLN2 →	+0.441	+0.060	<.001	<.001	3	6
BRCA	ADARB1 →	+0.325	+0.087	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.557	+0.066	<.001	.001	3	6
COAD	AGO3 →	+0.210	+0.056	.001	<.001	3	6
COAD	CSRP1 →	+0.746	+0.051	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060501 vs SPON1 — BRCA

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