Positive regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPAP1, PDE4DIPP2, and RCAN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation involved in lung morphogenesis activity versus SIRPAP1 in OV (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIRPAP1 →	-0.327	-0.196	<.001	.001	3	3
OV	PDE4DIPP2 →	-0.676	-0.199	<.001	<.001	3	3
UCEC	RCAN2 →	-0.770	-0.163	.006	.004	3	3
GBM	SAPCD2 →	+0.890	+0.268	.007	.001	3	3
GBM	RAB43P1 →	-0.348	-0.220	.006	.009	3	3
BRCA	GUCY1B2 →	-1.538	-0.642	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060501 vs SIRPAP1 — OV

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