Positive regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF443, BFAR, and ANKRD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF443 grouped by Positive regulation of epithelial cell proliferation involved in lung morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF443 →	-1.186	-1.553	<.001	.003	3	4
SOFT_TISSUE	BFAR →	+0.481	+1.398	.001	<.001	3	3
STOMACH	ANKRD1 →	+2.749	+0.841	.004	.003	2	4
STOMACH	TRIM16 →	+1.686	+0.372	<.001	.001	2	4
SOFT_TISSUE	SP9 →	-1.992	-1.230	.001	<.001	3	3
OESOPHAGUS	CDKN1A →	+1.312	+0.879	.006	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF443 by Positive regulation of epithelial cell proliferation involved in lung morphogenesis activity — LIVER

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