Positive regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the total protein of multiple features, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Gab2, Rad50, and PEA-15, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation involved in lung morphogenesis activity versus Gab2 in OESOPHAGUS (Pearson r = 0.89).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Gab2 →	+1.730	+0.192	.005	.029	2	1
OESOPHAGUS	Rad50 →	+0.571	+0.192	.005	.029	2	1
OESOPHAGUS	PEA-15 →	+0.615	+0.192	.015	.029	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest associations by consensus.

GO:0060501 vs Gab2 — OESOPHAGUS

Explore this scatter interactively →