Positive regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the drug response of multiple features, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AS605240, Wee1 Inhibitor, and Nutlin-3a (-), each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AS605240 grouped by Positive regulation of epithelial cell proliferation involved in lung morphogenesis-low versus -high activity in STOMACH.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AS605240 →	-0.694	-0.114	.024	.025	1	3
UPPER_AERODIGESTIVE_TRACT	Wee1 Inhibitor →	+0.874	+0.143	.029	.032	3	1
UPPER_AERODIGESTIVE_TRACT	Nutlin-3a (-) →	+0.525	+0.143	.009	.032	3	1
UPPER_AERODIGESTIVE_TRACT	Temozolomide →	+0.943	+0.143	<.001	.032	3	1
UPPER_AERODIGESTIVE_TRACT	HG6-64-1 →	+0.524	+0.143	.019	.032	3	1
UPPER_AERODIGESTIVE_TRACT	GSK2606414 →	+0.665	+0.174	.043	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AS605240 by Positive regulation of epithelial cell proliferation involved in lung morphogenesis activity — STOMACH

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