Regulation of cell projection assembly

Across TCGA patient cohorts, RNA activity of the Regulation of cell projection assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, YME1L1, and PALM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell projection assembly activity versus CLPX in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLPX →	-0.274	-0.042	<.001	.004	3	9
BRCA	YME1L1 →	-0.367	-0.034	<.001	<.001	3	9
GBM	PALM →	+0.592	+0.042	<.001	<.001	3	8
CCRCC	PRKG1 →	+0.513	+0.026	<.001	<.001	3	8
CCRCC	RPL5 →	-0.246	-0.038	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.718	+0.048	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060491 vs CLPX — HNSC

Explore this scatter interactively →