Regulation of cell projection assembly

Across TCGA cell cohorts, RNA activity of the Regulation of cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAVER1, ZNF771, and CCDC80, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAVER1 grouped by Regulation of cell projection assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RAVER1 →	-0.879	-0.252	.004	.004	2	5
PANCREAS	ZNF771 →	-0.861	-0.232	.002	.007	3	4
LUNG_NSCLC_LUSC	CCDC80 →	+6.028	+0.254	.001	.004	3	4
LARGE_INTESTINE	PKP2 →	+1.816	+0.227	.004	.002	3	4
LARGE_INTESTINE	FEM1A →	-0.641	-0.222	<.001	<.001	3	4
BREAST	ADAT3 →	-0.886	-0.145	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAVER1 by Regulation of cell projection assembly activity — PANCREAS

Explore this box plot interactively →