Lobar bronchus development

pathway activity — cross-omics
GO:0060482Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Lobar bronchus development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCNT3, PRKAG2-AS1, and AGR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECGCNT3 →+0.972+0.497.007.00335
GBMPRKAG2-AS1 →+1.593+0.173.005.00234
UCECAGR2 →+2.460+0.614<.001.00234
UCECTFF1 →+1.937+0.429.001.00634
UCECZG16B →+0.838+0.380.005.00825
HNSCMUC5B →+1.985+0.565<.001.00933
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration