Lobar bronchus epithelium development

pathway activity — cross-omics
GO:0060481Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Lobar bronchus epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TFF3, URB2, and BOP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTFF3 →+1.176+0.141<.001<.00137
BRCAURB2 →-0.372-0.160<.001<.00137
BRCABOP1 →-0.266-0.138<.001<.00137
BRCAAGR2 →+1.193+0.172<.001<.00137
BRCADDX18 →-0.351-0.141<.001<.00137
BRCAMLPH →+0.883+0.175<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration