Lung cell differentiation

Across TCGA patient cohorts, RNA activity of the Lung cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TC2N_S156, DDAH1, and CMBL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung cell differentiation activity versus TC2N_S156 in BRCA (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TC2N_S156 →	+1.148	+0.037	.001	.004	3	7
CCRCC	DDAH1 →	+0.592	+0.070	<.001	<.001	3	7
BRCA	CMBL →	+0.847	+0.040	<.001	<.001	3	7
LUAD	C8orf37_S96 →	+0.531	+0.030	.004	.008	3	6
CCRCC	COLGALT1 →	-0.387	-0.060	.001	.002	3	6
BRCA	CRIP2 →	+0.604	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060479 vs TC2N_S156 — BRCA

Explore this scatter interactively →