Lung cell differentiation

Across TCGA patient cohorts, RNA activity of the Lung cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIB, CWF19L2, and ID4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung cell differentiation activity versus NFIB in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFIB →	+0.837	+0.148	<.001	<.001	3	5
BRCA	CWF19L2 →	+0.360	+0.136	.004	.008	3	5
LUAD	ID4 →	+0.921	+0.197	<.001	.003	3	4
LUAD	KIF18B →	-0.773	-0.148	<.001	<.001	3	4
UCEC	RSRC2 →	+0.434	+0.250	<.001	<.001	3	4
GBM	YAP1 →	+0.992	+0.214	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060479 vs NFIB — UCEC

Explore this scatter interactively →