Lung cell differentiation

Across TCGA cell cohorts, RNA activity of the Lung cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THRB, CNGA1, and CNTNAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THRB grouped by Lung cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	THRB →	+0.894	+0.870	.002	.001	2	5
LUNG_NSCLC_LUAD	CNGA1 →	+0.608	+0.899	.001	<.001	3	4
LUNG_SCLC	CNTNAP1 →	-1.570	-1.597	.008	<.001	3	4
SOFT_TISSUE	MRGBP →	-1.182	-1.972	.009	<.001	3	4
STOMACH	TMEM30A →	+1.049	+1.189	.003	.007	3	4
SOFT_TISSUE	HSPBP1 →	-0.816	-1.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THRB by Lung cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →