Lung cell differentiation

Across TCGA cell cohorts, RNA activity of the Lung cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTHL1, GDF3, and PGR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NTHL1 grouped by Lung cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTHL1 →	+0.167	+0.105	<.001	.007	3	4
LUNG_NSCLC_LUAD	GDF3 →	+0.145	+0.107	<.001	.007	3	4
LUNG_SCLC	PGR →	+0.262	+0.228	.007	.008	3	4
KIDNEY	TAC1 →	+0.298	+0.319	.001	<.001	3	4
CNS	SEMA4B →	+0.283	+0.218	<.001	.001	3	4
CNS	PWWP3A →	-0.183	-0.260	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NTHL1 by Lung cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →