Lung cell differentiation

Across TCGA cell cohorts, RNA activity of the Lung cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF24, HIBCH, and RHPN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung cell differentiation activity versus ZNF24 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF24 →	+1.105	+1.348	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	HIBCH →	+0.674	+1.329	.002	.007	3	3
LARGE_INTESTINE	RHPN2 →	+0.638	+0.966	.005	.002	3	3
URINARY_TRACT	TAF4 →	+0.903	+1.782	.003	<.001	3	3
PANCREAS	SLC25A51 →	+0.940	+1.758	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	BCL7B →	+0.649	+1.482	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060479 vs ZNF24 — UPPER_AERODIGESTIVE_TRACT

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