Prevention of polyspermy

Across TCGA patient cohorts, RNA activity of the Prevention of polyspermy pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS2, EIF3G, and CCN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prevention of polyspermy activity versus ADAMTS2 in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADAMTS2 →	+1.266	+0.695	<.001	<.001	2	5
LSCC	EIF3G →	-0.326	-0.805	.001	.001	3	4
COAD	CCN4 →	+0.996	+0.568	<.001	.005	3	3
COAD	FN1 →	+1.492	+0.640	<.001	<.001	3	3
COAD	ADAMTS12 →	+0.775	+0.499	.001	.004	3	3
COAD	COL1A2 →	+1.666	+0.642	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060468 vs ADAMTS2 — COAD

Explore this scatter interactively →