Negative regulation of digestive system process

Across TCGA patient cohorts, RNA activity of the Negative regulation of digestive system process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK39, RPRD2, and MTA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of digestive system process activity versus STK39 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STK39 →	+0.565	+0.121	<.001	<.001	3	6
OV	RPRD2 →	-0.256	-0.073	<.001	<.001	3	5
OV	MTA1 →	-0.380	-0.071	<.001	.002	3	5
GBM	EHD4 →	+0.313	+0.081	<.001	<.001	3	5
BRCA	GAPDH_T153 →	+1.944	+0.161	.002	<.001	3	5
GBM	GINS4 →	-0.391	-0.087	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060457 vs STK39 — LUAD

Explore this scatter interactively →