Negative regulation of digestive system process

Across TCGA patient cohorts, RNA activity of the Negative regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC18-AS1, SEC24B-AS1, and RELL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of digestive system process activity versus CCDC18-AS1 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCDC18-AS1 →	+0.685	+0.325	<.001	<.001	3	4
PDAC	SEC24B-AS1 →	+0.274	+0.808	<.001	<.001	3	4
COAD	RELL1 →	-0.688	-0.213	<.001	.001	3	4
PDAC	ZNF799 →	+0.308	+0.874	<.001	<.001	3	4
COAD	BATF3 →	-0.524	-0.204	.001	<.001	3	3
LSCC	BCAN →	-0.666	-0.778	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060457 vs CCDC18-AS1 — BRCA

Explore this scatter interactively →