Negative regulation of digestive system process

Across TCGA cell cohorts, RNA activity of the Negative regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM134, FOXD1, and GGT7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM134 grouped by Negative regulation of digestive system process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMEM134 →	-1.663	-2.068	.004	<.001	3	4
BLOOD_Myeloma	FOXD1 →	+1.140	+1.045	.004	.001	3	3
PANCREAS	GGT7 →	+1.295	+0.810	.008	.007	2	4
LUNG_SCLC	P2RX5 →	-2.395	-0.965	.001	.009	2	4
LUNG_NSCLC_LUAD	CACHD1 →	+0.899	+0.559	.006	.008	3	3
OVARY	PUM1 →	-0.719	-1.250	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM134 by Negative regulation of digestive system process activity — BLOOD_Lymphoma

Explore this box plot interactively →