Positive regulation of digestive system process

Across TCGA patient cohorts, RNA activity of the Positive regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNP, VIPR1, and LGALS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of digestive system process activity versus CCNP in COAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCNP →	-0.621	-0.149	.006	.005	3	4
BRCA	VIPR1 →	+0.576	+0.422	.005	.003	3	4
BRCA	LGALS4 →	+0.429	+0.445	<.001	.009	3	4
GBM	SULT4A1 →	+1.353	+0.605	<.001	.001	3	4
COAD	CAB39L →	+0.768	+0.178	.006	.009	3	3
UCEC	KIF20A →	-0.727	-0.485	.002	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060456 vs CCNP — COAD

Explore this scatter interactively →