Regulation of gastric acid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of gastric acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP4B1, CCSAP, and IL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gastric acid secretion activity versus CYP4B1 in LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CYP4B1 →	+1.312	+0.406	<.001	.009	3	4
UCEC	CCSAP →	-0.529	-0.746	<.001	.001	3	4
LSCC	IL5 →	+0.396	+0.859	.002	<.001	3	3
LUAD	TRIM22 →	+0.635	+0.847	<.001	<.001	3	3
LUAD	RNF144B →	+0.507	+0.478	<.001	.001	3	3
LSCC	FLI1 →	+0.495	+0.710	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060453 vs CYP4B1 — LUAD

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