Regulation of gastric acid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of gastric acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KCNQ1_S27, YRDC, and SPEN_S2120, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gastric acid secretion activity versus KCNQ1_S27 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KCNQ1_S27 →	+1.143	+0.831	<.001	<.001	3	4
COAD	YRDC →	-0.683	-0.695	<.001	.002	3	3
UCEC	SPEN_S2120 →	-0.784	-1.249	<.001	<.001	2	4
UCEC	CAVIN2_S16 →	+0.888	+0.776	<.001	<.001	3	3
CCRCC	PDZRN3 →	+0.510	+1.267	<.001	<.001	3	3
GBM	SNX29_S642 →	-0.705	-1.174	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060453 vs KCNQ1_S27 — BRCA

Explore this scatter interactively →