Regulation of gastric acid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of gastric acid secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGER3, GTPBP1, and TFF2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGER3 grouped by Regulation of gastric acid secretion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTGER3 →	-0.430	-1.635	<.001	<.001	3	13
LUNG_NSCLC_LUAD	GTPBP1 →	-0.337	-0.833	<.001	.001	3	6
OVARY	TFF2 →	-0.200	-1.175	.007	.001	3	6
LUNG_NSCLC_LUAD	ADGRD2 →	-0.192	-0.627	.001	.007	3	5
LIVER	PTPN6 →	+0.144	+1.098	.001	.003	3	5
OVARY	FGD5 →	-0.158	-0.932	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGER3 by Regulation of gastric acid secretion activity — BLOOD_Leukemia

Explore this box plot interactively →