Regulation of gastric acid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of gastric acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF66, ZNF490, and ZNF43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF66 grouped by Regulation of gastric acid secretion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF66 →	-0.836	-1.035	.001	<.001	3	3
OVARY	ZNF490 →	-0.649	-1.048	<.001	.006	3	3
KIDNEY	ZNF43 →	-2.001	-1.068	.001	.008	3	3
OVARY	NME1 →	+0.634	+0.894	.007	.002	3	3
LIVER	C4orf48 →	-1.268	-0.365	.009	.007	2	4
BLOOD_Myeloma	TMEM59L →	-0.332	-0.282	.009	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF66 by Regulation of gastric acid secretion activity — OVARY

Explore this box plot interactively →