Positive regulation of cardiac muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of cardiac muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBL4A_S90, DSTN_S24, and HEPH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiac muscle contraction activity versus UBL4A_S90 in HNSC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBL4A_S90 →	-0.748	-0.118	<.001	.002	3	6
OV	DSTN_S24 →	+0.804	+0.095	.004	.006	3	6
OV	HEPH →	+0.698	+0.113	<.001	<.001	3	6
UCEC	FNDC1 →	+0.620	+0.110	.006	.004	3	6
LSCC	CALD1_S73 →	+0.898	+0.119	<.001	<.001	3	6
HNSC	SNX1_S72 →	-0.604	-0.135	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060452 vs UBL4A_S90 — HNSC

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