Positive regulation of cardiac muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTC1, CYTH1, and ARMC7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTC1 grouped by Positive regulation of cardiac muscle contraction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CTC1 →	+1.261	+1.437	.001	.002	3	5
SKIN	CYTH1 →	+0.595	+0.821	<.001	.003	3	4
PANCREAS	ARMC7 →	+0.847	+1.538	<.001	<.001	3	4
SKIN	APPBP2 →	+0.428	+0.869	.002	.001	3	4
CNS	CENPV →	+1.903	+0.938	<.001	.004	3	4
LUNG_SCLC	DLL4 →	+2.705	+1.683	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTC1 by Positive regulation of cardiac muscle contraction activity — LUNG_SCLC

Explore this box plot interactively →