Branching involved in salivary gland morphogenesis

pathway activity — cross-omics
GO:0060445Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Branching involved in salivary gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NID1, LAMA5, and ITGB1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
TGCTNID1 →+2.494+0.104<.001<.001328
THYMLAMA5 →+1.747+0.085<.001<.001327
THYMITGB1 →+1.673+0.075<.001<.001327
THYMLAMC1 →+1.478+0.091<.001<.001326
THYMFNDC3B →+1.465+0.082<.001<.001326
TGCTEXT1 →+1.644+0.094<.001<.001326
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration