Branching involved in mammary gland duct morphogenesis

pathway activity — cross-omics
GO:0060444Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Branching involved in mammary gland duct morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CST3_S43, LPCAT2, and LAMB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCCST3_S43 →+0.422+0.060<.001.00135
COADLPCAT2 →+0.250+0.035<.001.00135
LSCCLAMB3 →+0.683+0.058.001<.00135
UCECRFC1_T506 →-0.671-0.076.005.00935
UCECSH3GLB1 →+0.215+0.091.002<.00135
BRCAMTA1_T564 →-1.046-0.085<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration