Mammary gland morphogenesis

Across TCGA cell cohorts, RNA activity of the Mammary gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, SAA1, and C20orf96, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP16 grouped by Mammary gland morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DUSP16 →	+0.695	+0.965	.001	<.001	3	5
OVARY	SAA1 →	-4.021	-1.163	.003	.004	3	5
CNS	C20orf96 →	+0.741	+0.997	<.001	.001	3	5
CNS	CXCL8 →	-2.689	-0.900	<.001	<.001	3	5
SOFT_TISSUE	C11orf80 →	+0.840	+1.066	<.001	.009	3	4
OVARY	OTX1 →	+0.740	+1.196	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP16 by Mammary gland morphogenesis activity — SKIN

Explore this box plot interactively →