Trachea formation

pathway activity — cross-omics
GO:0060440Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Trachea formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RANBP2, TOP2B_S1522, and AMBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARANBP2 →-0.194-0.060.001<.00136
OVTOP2B_S1522 →-1.203-0.063.001<.00135
OVAMBP →+0.626+0.052<.001<.00135
BRCADNAJC7 →-0.255-0.048.004.00835
GBMPRPF3 →-0.228-0.080<.001<.00135
GBMCAPN2 →+0.514+0.090<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration