Trachea formation

pathway activity — cross-omics
GO:0060440Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Trachea formation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR22HG, RNVU1-30, and MIR3193, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACMIR22HG →+0.464+0.261<.001<.00135
PDACRNVU1-30 →+0.747+0.344<.001<.00135
UCECMIR3193 →+1.410+0.174.002.00535
HNSCSNRK-AS1 →+0.331+0.124.006.00235
UCECSELENOP →+0.690+0.164.003.00235
LUADKLF2 →+0.578+0.148<.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration