Trachea development

Across TCGA patient cohorts, RNA activity of the Trachea development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNVU1-30, XPA, and TEF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trachea development activity versus RNVU1-30 in COAD (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNVU1-30 →	+0.629	+0.187	.001	<.001	3	4
UCEC	XPA →	+0.305	+0.148	.005	.002	2	5
HNSC	TEF →	+0.582	+0.110	.005	.003	3	4
UCEC	MIR3193 →	+1.228	+0.162	.004	.002	3	4
LUAD	MIR27B →	+0.743	+0.196	.004	.001	3	4
GBM	CDC14B →	+0.465	+0.168	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060438 vs RNVU1-30 — COAD

Explore this scatter interactively →