Lung epithelium development

Across TCGA patient cohorts, RNA activity of the Lung epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XRN1, SEPTIN4, and BOP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung epithelium development activity versus XRN1 in OV (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XRN1 →	-0.248	-0.051	<.001	<.001	3	7
PDAC	SEPTIN4 →	+0.562	+0.057	<.001	<.001	3	7
BRCA	BOP1 →	-0.311	-0.031	<.001	<.001	3	7
GBM	ADD3 →	+0.495	+0.079	<.001	<.001	3	7
CCRCC	DDAH1 →	+0.576	+0.064	<.001	<.001	3	7
BRCA	DNAJC7 →	-0.276	-0.042	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060428 vs XRN1 — OV

Explore this scatter interactively →