Lung epithelium development

Across TCGA patient cohorts, RNA activity of the Lung epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV8-4, DARS1, and THOC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung epithelium development activity versus TRAV8-4 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAV8-4 →	-0.562	-0.132	.005	.009	3	5
UCEC	DARS1 →	+0.573	+0.195	<.001	<.001	3	4
UCEC	THOC6 →	+0.765	+0.141	.003	.003	3	4
UCEC	MICA →	+0.777	+0.173	.001	.004	3	4
COAD	CCT6P1 →	+0.371	+0.117	.003	.008	2	5
UCEC	THAP3 →	+0.532	+0.111	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060428 vs TRAV8-4 — LSCC

Explore this scatter interactively →