Lung epithelium development

Across TCGA cell cohorts, RNA activity of the Lung epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFL8, ZNF322, and PCOLCE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EGFL8 grouped by Lung epithelium development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EGFL8 →	-1.754	-1.626	.004	<.001	3	6
BONE	ZNF322 →	+0.558	+1.669	.007	<.001	3	5
OVARY	PCOLCE →	-1.687	-1.116	.001	<.001	3	4
OVARY	NEURL2 →	-0.777	-1.287	.003	<.001	3	4
BLOOD_Myeloma	NF2 →	+0.849	+1.518	<.001	.002	3	4
KIDNEY	SYDE1 →	-0.682	-1.355	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EGFL8 by Lung epithelium development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →