Lung epithelium development

Across TCGA cell cohorts, RNA activity of the Lung epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP51, TRIM65, and CLCN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung epithelium development activity versus USP51 in LUNG_NSCLC_LUSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	USP51 →	+0.231	+1.693	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TRIM65 →	+1.086	+1.394	.008	.008	3	4
CNS	CLCN6 →	+0.844	+1.243	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	GPR68 →	+1.807	+1.134	<.001	.009	3	3
SKIN	KHDRBS1 →	+0.600	+1.705	.001	<.001	3	3
CNS	KIF15 →	+1.058	+1.396	.004	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060428 vs USP51 — LUNG_NSCLC_LUSC

Explore this scatter interactively →