Lung vasculature development

Across TCGA patient cohorts, RNA activity of the Lung vasculature development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A1, FSTL1, and P3H3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung vasculature development activity versus COL5A1 in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL5A1 →	+0.643	+0.104	.002	<.001	3	6
UCEC	FSTL1 →	+0.520	+0.117	.003	<.001	3	6
GBM	P3H3 →	+0.611	+0.120	<.001	<.001	3	6
GBM	S100P →	+1.452	+0.110	<.001	<.001	3	6
GBM	PLOD1 →	+0.637	+0.134	<.001	<.001	3	6
GBM	S100A10 →	+0.620	+0.121	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060426 vs COL5A1 — GBM

Explore this scatter interactively →