Lung vasculature development

Across TCGA patient cohorts, RNA activity of the Lung vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERRFI1, PLIN2, and ITGB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung vasculature development activity versus ERRFI1 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERRFI1 →	+1.319	+0.307	<.001	.001	1	7
LSCC	PLIN2 →	+0.719	+0.238	<.001	.001	3	5
PDAC	ITGB1 →	+0.361	+0.177	.003	.007	3	5
COAD	RASD1 →	+0.576	+0.519	.007	.003	3	4
BRCA	NDRG1 →	+0.976	+0.207	<.001	<.001	3	4
BRCA	ACOT9 →	+0.550	+0.255	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060426 vs ERRFI1 — UCEC

Explore this scatter interactively →