Lung vasculature development

Across TCGA cell cohorts, RNA activity of the Lung vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK7, SMIM22, and RPS18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DOK7 grouped by Lung vasculature development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DOK7 →	-1.942	-0.860	.001	.003	3	5
PANCREAS	SMIM22 →	-4.087	-0.992	.001	.008	3	5
OESOPHAGUS	RPS18 →	+0.796	+1.166	<.001	.001	3	4
STOMACH	DUS4L →	-0.754	-0.820	.004	.005	3	4
PANCREAS	HJURP →	+0.629	+0.825	.002	.009	3	4
LUNG_SCLC	MECR →	-0.574	-1.008	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DOK7 by Lung vasculature development activity — BREAST

Explore this box plot interactively →