Lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL3_S522, SLC25A19, and ZYX_S344, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung morphogenesis activity versus DPYSL3_S522 in BRCA (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DPYSL3_S522 →	+0.445	+0.032	.004	<.001	3	5
LSCC	SLC25A19 →	-0.344	-0.051	<.001	.001	3	4
LSCC	ZYX_S344 →	+0.550	+0.038	.001	.005	3	4
LSCC	CST3 →	+0.249	+0.053	.001	<.001	3	4
BRCA	ANXA2 →	+0.249	+0.023	.004	.003	3	4
LSCC	ANXA4 →	+0.238	+0.044	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060425 vs DPYSL3_S522 — BRCA

Explore this scatter interactively →