Positive regulation of heart growth

Across TCGA patient cohorts, RNA activity of the Positive regulation of heart growth pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SVEP1, TCF4, and SLIT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of heart growth activity versus SVEP1 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SVEP1 →	+1.089	+0.961	<.001	<.001	3	6
BRCA	TCF4 →	+0.713	+0.840	<.001	<.001	3	6
BRCA	SLIT2 →	+0.704	+0.855	<.001	<.001	3	5
LUAD	COX7A1 →	+0.393	+0.528	.004	.002	3	5
BRCA	ABCA9 →	+0.899	+0.851	<.001	<.001	3	5
BRCA	SCARF2 →	+0.831	+0.787	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060421 vs SVEP1 — BRCA

Explore this scatter interactively →