Positive regulation of heart growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of heart growth pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIPC1, ORC2, and ARL4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GIPC1 grouped by Positive regulation of heart growth-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GIPC1 →	+0.702	+0.327	<.001	.006	3	4
LUNG_NSCLC_LUSC	ORC2 →	+0.725	+0.361	.001	<.001	3	3
LUNG_NSCLC_LUSC	ARL4A →	+0.929	+0.318	.001	.004	3	3
STOMACH	PRRG1 →	+1.718	+0.380	.002	<.001	3	3
LARGE_INTESTINE	TRIP12 →	+0.620	+0.297	.001	.003	3	3
LARGE_INTESTINE	FASTK →	+0.465	+0.320	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GIPC1 by Positive regulation of heart growth activity — LARGE_INTESTINE

Explore this box plot interactively →