Regulation of heart growth

Across TCGA patient cohorts, RNA activity of the Regulation of heart growth pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRA, IGFBP4, and TSHZ3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart growth activity versus PDGFRA in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDGFRA →	+0.724	+0.541	.002	.003	2	5
OV	IGFBP4 →	+0.976	+0.815	.006	.009	3	4
CCRCC	TSHZ3 →	+0.451	+0.557	.001	.009	2	4
OV	LAMA4 →	+0.896	+0.831	.004	.007	3	3
BRCA	RHOJ →	+0.654	+0.643	.003	.002	3	3
OV	IGFBP7 →	+0.666	+0.775	.008	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060420 vs PDGFRA — BRCA

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