Regulation of heart growth

Across TCGA cell cohorts, RNA activity of the Regulation of heart growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, CORO6, and ZNF765, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart growth activity versus BASP1 in BLOOD_Lymphoma (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BASP1 →	+3.045	+0.563	<.001	.001	3	4
OESOPHAGUS	CORO6 →	+2.081	+0.450	.001	<.001	3	4
BLOOD_Leukemia	ZNF765 →	-0.579	-0.309	<.001	.001	3	3
LARGE_INTESTINE	GATA3 →	+1.535	+0.504	<.001	.007	2	4
PANCREAS	RECK →	+1.188	+0.251	.004	.008	3	3
LARGE_INTESTINE	TRPC1 →	+1.437	+0.607	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060420 vs BASP1 — BLOOD_Lymphoma

Explore this scatter interactively →