Heart growth

Across TCGA cell cohorts, RNA activity of the Heart growth pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM6B, TSPAN15, and CAMSAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM6B grouped by Heart growth-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KDM6B →	+1.481	+1.420	.003	.001	3	4
CNS	TSPAN15 →	+1.794	+0.843	.002	.001	3	4
BONE	CAMSAP1 →	+0.706	+1.386	.004	.001	3	4
BONE	CTC1 →	+0.953	+1.442	.004	<.001	3	4
LARGE_INTESTINE	HOXC6 →	-1.278	-1.081	.005	.001	3	4
URINARY_TRACT	EBPL →	+1.323	+1.477	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM6B by Heart growth activity — LUNG_SCLC

Explore this box plot interactively →