Heart growth

Across TCGA cell cohorts, RNA activity of the Heart growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM5, MVP, and DLC1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart growth activity versus PDLIM5 in BLOOD_Leukemia (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDLIM5 →	+2.159	+1.646	.001	<.001	3	11
SOFT_TISSUE	MVP →	+2.885	+2.283	.007	<.001	3	5
SOFT_TISSUE	DLC1 →	+4.478	+2.283	<.001	<.001	3	5
SOFT_TISSUE	TSPAN5 →	+4.980	+2.283	<.001	<.001	3	5
LUNG_SCLC	TIPARP →	+0.791	+0.941	.001	.002	3	5
SOFT_TISSUE	TFPI →	+5.655	+2.461	.003	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060419 vs PDLIM5 — BLOOD_Leukemia

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