Response to growth hormone

Across TCGA patient cohorts, RNA activity of the Response to growth hormone pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYPC, DNAJA3, and THOP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to growth hormone activity versus GYPC in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GYPC →	+0.637	+0.169	.001	.001	3	5
LSCC	DNAJA3 →	-0.460	-0.266	<.001	<.001	3	4
LSCC	THOP1 →	-0.513	-0.227	<.001	.004	3	4
LSCC	UBQLN4 →	-0.510	-0.236	.002	.003	3	4
LSCC	VRK1 →	-0.568	-0.199	.001	.001	3	4
LSCC	MAZ →	-0.397	-0.245	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060416 vs GYPC — GBM

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