Response to growth hormone

Across TCGA cell cohorts, RNA activity of the Response to growth hormone pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRU, SLK, and PCMT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to growth hormone activity versus PTPRU in LUNG_SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTPRU →	+2.458	+0.246	.001	.002	3	4
BLOOD_Myeloma	SLK →	-1.012	-0.510	.009	<.001	3	4
BLOOD_Leukemia	PCMT1 →	-0.466	-0.227	.006	.002	3	3
LUNG_SCLC	WBP4 →	-0.501	-0.187	.001	.002	2	4
LUNG_SCLC	YME1L1 →	-0.583	-0.195	.004	.003	3	3
LUNG_SCLC	SUOX →	-0.924	-0.200	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060416 vs PTPRU — LUNG_SCLC

Explore this scatter interactively →