Aorta smooth muscle tissue morphogenesis

Across TCGA cell cohorts, RNA activity of the Aorta smooth muscle tissue morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADK, PLRG1, and SMARCE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADK grouped by Aorta smooth muscle tissue morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADK →	-0.122	-1.075	<.001	<.001	3	5
CNS	PLRG1 →	-0.343	-0.761	<.001	.002	3	5
BREAST	SMARCE1 →	-0.302	-0.765	<.001	.001	3	5
STOMACH	CYP27B1 →	+0.235	+1.539	<.001	.009	3	4
LIVER	ZBTB24 →	-0.253	-0.341	.002	.003	3	4
LUNG_NSCLC_LUSC	EBNA1BP2 →	-0.426	-1.972	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADK by Aorta smooth muscle tissue morphogenesis activity — SKIN

Explore this box plot interactively →