Aorta smooth muscle tissue morphogenesis

Across TCGA cell cohorts, RNA activity of the Aorta smooth muscle tissue morphogenesis pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Cytarabine, Sinularin, and BAY-MPS-combo-1 (paclitaxel 5 uM), each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Cytarabine grouped by Aorta smooth muscle tissue morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytarabine →	+1.536	+1.207	.027	.040	3	2
LUNG_SCLC	Sinularin →	+0.780	+0.515	.009	.034	3	2
LUNG_SCLC	BAY-MPS-combo-1 (paclitaxel 5 uM) →	+1.050	+0.611	.011	.021	3	1
LUNG_SCLC	BAY-MPS-combo 2 (paclitaxel 1 uM) →	+0.790	+0.759	.011	.023	3	1
LUNG_SCLC	Midostaurin →	-0.810	-1.387	.015	.026	3	1
LUNG_SCLC	JAK1_8709 →	+0.853	+0.515	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cytarabine by Aorta smooth muscle tissue morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →