Regulation of growth hormone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of growth hormone receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCAF13, DOCK8, and EDC4_S879, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of growth hormone receptor signaling pathway activity versus DCAF13 in LSCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DCAF13 →	-0.365	-0.066	<.001	<.001	3	6
LSCC	DOCK8 →	+0.341	+0.046	<.001	<.001	3	6
LSCC	EDC4_S879 →	-0.392	-0.054	.003	.002	3	6
LSCC	ESF1 →	-0.395	-0.053	<.001	<.001	3	5
OV	APOBEC3C →	+0.654	+0.046	<.001	.001	3	5
UCEC	TMEM163_S12 →	+0.606	+0.098	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060398 vs DCAF13 — LSCC

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